Yup, it gives it a new feel. I changed both my url and title for a change.
from; torturedmannequin.blogspot to snsdiscussion.blogspot
as for the title it was 'the digital native talks' where as now its 'sns discussions' - for me it was more simple and to the point. It tilts the conversation towards the target readers and as I said I just needed something different. I still include a little subtext under the title that I change monthly with a new quote, currently its 'And hark! the digital native spoke the words....(insert quote etc)'
So I get to keep a similarity with the old title but shake it up.
It all depends on what your after